RabMabs on extracellular matrix research

The extracellular matrix (ECM) is a three-dimensional, non-cellular, highly dynamic structure that is present in all tissues and continuously undergoes controlled remodeling process where ECM components are deposited, degraded, or otherwise modified. Components of the ECM constantly interact with epithelial cells by serving as ligands for cell receptors such as integrins, discoidin domain receptors (DDRs), CD44 and syndecans, thereby transmitting signals that regulate adhesion, migration, proliferation, apoptosis, survival or differentiation. Abnormal ECM dynamics lead to deregulated cell proliferation and invasion, failure of cell death, and loss of cell differentiation, resulting in congenital defects and pathological processes including tissue fibrosis and cancer.

Selected antibodies for extracellular matrix research

Rabbit monoclonal antibodies from ABclonal.

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