RabMabs on cell adhesion

Cell adhesion is the process by which cells form contacts with neighboring cell through specialized protein complexes of the cell surface. It can be either direct, through cell junctions, or indirect, by attaching to the extracellular matrix (ECM), and it is essential for many cellular preocesses such as cell migration and tissue development. Cell junction forms when cell adhere to one another and it can be classified into two main types, cell-cell junctions, which are mainly mediated by cadherins, and cell-matrix junctions, which are mainly mediated by integrins, and multi-protein adhesion structures such as focal adhesions, and hemidesmosomes. Many other relevant proteins also participate in the process including immunoglobin (Ig) superfamily members and selectins. Since cell adhesion can be involved in many different signal transduction pathways, it is vital for the survival, differentiation, and migration of cells. Aberration in cell adhesion can lead to diverse pathologies, such as cancer metastasis, vascular disease, and inflammation.

Selected antibodies for cell adhesion

Rabbit monoclonal antibodies from ABclonal.

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